Clinical Studies and tests were conducted using BriAA‘s component and technology in order to measure the stimulation of all key participants of the sophisticated skin reconstruction synthesis. The stimulated activity was examined and compared using Day & Night Creams components against a control panel. Advanced software, optical and technological means of examination were used to assess and evaluate the results.

3 Various studies have shown spectacular results, proving improvement in all tested measures.

Within just two months, a considerable reduction in the volume and depth of wrinkles was observed.

Laboratory research on natural skin tissue and dermis cells obtained conclusions that proved beyond doubt the effect of BriAA’s components, in creating a synthesis expressed in empowering activity of skin cells as collagen.
The results showed:

Tests conducted on natural skin explants as well as HDF (Human Dermal Fibroblasts) presented:

The Synthesis in Collagen I (HFD):

The Synthesis in Collagen I (HFD): Control

Control

The Synthesis in Collagen I (HFD): BriAA Component

BriAA Component

The Synthesis in Collagen I (aged skin explants):

The Synthesis in Collagen I (aged skin explants): Control

Control

The Synthesis in Collagen I (aged skin explants): BriAA Component

BriAA Component

*Epidermis = black, Dermis = green

0%
An increase of 105% in Collagen I Synthesis.
0%
An increase of 48% in the presence of collagen I.
0%
An increase of 104% in the presence of collagen II.
0%
An increase of 174% in the presence of Hyaluronic Acid.
0%
An increase of 42% in collagen IV Synthesis.
0%
An increase of 75% in the Synthesis of laminin 5 at the Dermal-Epidermal connection.
Control

Control

BriAA Component: 0%Increase of 105% in the Collagen I synthesis initiation, 0%Increase of 48% in the presence of Collagen I0%, Increase of 104% in the presence of Collagen III0%, Increase of 174% in the presence of Hyaluronic Acid 0%, Increase of 42% in the synthesis of Collagen IV 0%, Increase of 75% in the Synthesis of Laminin-5 at the dermal-epidermal interface

BriAA Component

In Vivo Studies

Study conducted on 25 volunteers, monitoring the crow’s feet and the forehead lines for a period of two months. Advanced optical and technological means were used in order to evaluate skin’s condition and measure the changes in the volume and depth of the wrinkles as well as the complexity of the surface. The results:

Forehead Wrinkles Crow’s feet
31% Diminishment in volume 28% Decrease in deep wrinkled surface
28% Smoothing the wrinkles 21% Decrease in volume
16% Decrease in depth. 15% Decrease in depth
Day 0

Day 0

Day 60

Day 60

Day 0

Day 0

Day 60

Day 60

The study showed improvement in all parameters evaluated. Within only two months, constant and significant decrease in wrinkles volume and depth was achieved.

Second study

A further in vivo study focused on specific stimulation of contractions of the Collagen fibers was conducted. The study evaluated BriAA‘s component in contrast to vitamin C, a known powerful stimulator of Collagen contractions. The examination was performed on 15 volunteers, for a period of 28 days.

The results showed:

Third study

Dermatologist evaluation conducted on 35 women aged 40-60 for a period of 28 days. Results demonstrate the percentages of subjects with significant improvement:

Skin uniformity (waviness)  

72%

Roughness

64%

Depth of fine lines

60%

Reduction in wrinkle Volume

48%

Reduction in winkle depth

52%

Hydration content

80%

Closeup - Before

Before

Closeup - After

After

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